CART Fund 2017 Alzheimer’s Research Grants
The Coins for Alzheimer’s Research Trust Fund (CART) awarded $700,000 in Alzheimer’s research grants in May 2017. Awards to six researchers from US institutions.
The 2017 grants mark two records for CART. The $700,000 figure is the highest dollar amount of grants ever awarded by the organization. CART grants are funded by the generosity of Rotarians, starting with donations of coins and cash at weekly Rotary Club meetings.
The second record for the 2017 grants is the number of grants awarded.
2017 Major CART Grant Recipient
Research Project: Sleep enhancement: a strategy to improve cognitive performance in adult and Alzheimer’s disease mouse models
Our goal is to reduce the burden of Alzheimer’s disease. Cognitive impairment and sleep disruption represent two of the most disabling symptoms of Alzheimer’s disease and are the primary bases for institutionalization. Given that sleep disruption is known to cause cognitive deficits in the healthy individual, we hypothesize that increased sleep quantity and quality can improve cognitive function and reverse the cognitive deficits associated with Alzheimer’s disease. I have developed a mouse model of sleep enhancement permitting my laboratory to test, for the first time, whether sleep enhancement can improve cognitive function in cognitively impaired as well as un-impaired mice.
This project proposes to define the role of sleep in cognitive function, test whether or not increased sleep quality can improve cognition in the mouse, and develop newer mouse models to study sleep, cognition and Alzheimer’s disease. Successful completion of the aims will show that slow-wave-sleep (SWS) enhancement and rapid eye movement sleep (REMS) have different and complementary effects on cognitive function.